Bofoakwa Tano have their unbeaten start to the campaign at stake as they face Aduana FC in the betPawa Premier League.
The Hunters, are unbeaten in the seven matches they have played this season, but they face a herculean task on Wednesday as they visit the Nana Agyemang Badu I, Park, Dormaa-Ahenkro.
This is one of seven games coming up on Wednesday as the league continues with the Matchday Eight matches.
Aduana FC, have won all their three home games so far, and they will be favoured to collect the three points against a Bofoakwa Tano side that have drawn their last four games.
Champions Medeama SC, plays Accra Hearts of Oak in what should be a thriller at the Accra Sports Stadium with both sides needing the points for separate ambitions.
Hearts of Oak are in the relegation zone and needs the points to get out of the bottom three with Medeama SC seeking to the points to continue with the defence of the title they won last season.
Bottom side Nations FC will look for some respite as they welcome Real Tamale United to the Dr Kwame Kyei Sports Complex knowing a win today, can take them out of the relegation zone if other results go in their favour.
Dreams FC will fancy their chances of getting the result as they play at home to Berekum Chelsea at the Theatre of Dreams Park, Dawu.
Berekum Chelsea, have lost their last two games, and do need to up their game if they want to get something out of this fixture.
Bibiani Gold Stars will look for their first away win of the campaign as they trek up north to play Karela United at the Aliu Mahama Sports Stadium, Tamale.
United, have been unbeaten in their last three games, and will look to press home the advantage in front of their home fans.
FC Samartex will look to return to winning ways when they welcome Legon Cities to the Nsenkyire Sports Arena, Samreboi.
The Timber Giants, have picked just one point from their last two games, but at their home venue, they will aim for the three points.
Bechem United will host Accra Great Olympics at the Nana Fosu Gyeabour Park, Bechem in what should be a keenly contested affair on Wednesday afternoon before the midweek thrills continues with two more games on Thursday.